River of Blood/Quick guide

Preperations for Aeonisig

 * Talk to King Roald in Varrock Castle.
 * Talk to Drezel under Paterdomus Temple.
 * Reclaim the wolfbane dagger if you had previously destroyed it.
 * Talk to Aeonisig east of the Paterdomus light beacon.
 * Defeat the 3 Vyrewatches.
 * Talk to Aeonisig. (Chat option 1-4)
 * Talk to Captain Rovin to supply him with armour.
 * Talk to Aeonisig. (Chat options 3-3)
 * Kill all Zamorak monks in the temple.
 * Kill the Zamorak leader and bodyguard on the top floor.
 * Return to Aeonisig (Chat option 2-2-2)
 * Return to Drezel.
 * Climb-down the trapdoor.
 * Pull 7 books off the bookcases in the correct order until you find the "Blood of the Covenant": Lumbridge, Varrock, Edgeville, Falador, Rimmington, Taverley, Draynor, then finally "Blood of the Covenant".
 * Read the book.
 * Climb-up the ladder.
 * Talk to Ivan Strom.
 * Enter the trapdoor behind Canifis pub and take the first entrance on the east. If players are taken to Mort'ton they need to go to the Temple Trekking noticeboard next to the temple west of Canifis, click on the medium NPC and on the right hand side, they'll see the NPC with level 99, which is rewarded with the ability to toggle a shortcut from the trapdoor. After toggling it the door will function as normal or the boat can be taken back to the swamp and run to the cellar doors from here to access the tomb without toggling the function.
 * Use a Guthix balance on the tomb and open it.
 * Open the scroll case and read the Scroll of Balance.
 * Burn a Blisterwood log and take the ashes (no need to wait for the fire to extinguish).
 * Grind the Silvthril bar at the ectofuntus grinder.
 * Use the Silvthril dust on the Altar of Nature in the Nature Grotto.
 * Mix the Super Guthix balance potion.
 * Talk to Drezel.
 * Pour the potion into the nearby well.
 * Talk to Aeonisig. (Chat option 1-3)
 * Talk to Vanescula on the bridge.
 * Kill the feral vampyres.
 * Kill the Wyrd while stepping away from its special attacks.

Combatting haemalchemy

 * Travel on the boat south of Burgh de Rott to the Icyene graveyard.
 * Talk to Efaritay.
 * Inspect the northern crypt.
 * Talk to Efaritay.
 * Craft a Blisterwood shaft from Blisterwood logs.
 * Use the shaft on the Sunspear with the Wolfbane dagger in your inventory.
 * Talk to Efaritay.
 * Teleport to the Meiyerditch Laboratories.
 * Talk to Sarius.
 * Run through the tunnel to the room with the Mutated Bloodveld just to your west. Take the book from the research table on the north side and read it.
 * Talk to Sarius.
 * Climb the stairs and run northwest into the mine.
 * With your vampire disguise on, talk to a guard about the refinery. (if you don't have your disguise on you must manually fill the cart up with 15 ores yourself)
 * Push the cart.
 * Kill the Juvinates.
 * Open the 5 cell doors.

Refinery Puzzle

 * Run north and talk to Emilia. (Option 5)
 * Talk to Sorin. (Option 4)
 * Talk to Ileana. (Option 3)
 * Talk to Razvan. (Option 2)
 * Talk to Florin. (Option 1)
 * Tithe the Shadum blood lock. (Option 6)

Curing vampyrism

 * Extract the Refined daeyalt.
 * Inspect the rejuvination tank.
 * Climb the stairs and talk to Safalaan.
 * Kill the Skeleton Hellhounds.
 * Climb the stairs.
 * Find and take the bottle of holy water.
 * Throw it on Harold and climb the stairs.
 * Cut a log from the blisterwood tree.
 * Light the firepit in front of the Stone of Jas.
 * Roll the barrel of gunpowder.
 * Unlock the blood seal.
 * Climb the stairs.
 * Kill Safalan with the Sunspear.
 * Talk to Efaritay.
 * Use the daeyalt and Ivandis' serum on Safalan's blood.
 * Talk to Efaritay.
 * Pour the extreme Guthix balance potion into the Paterdomus well.
 * Talk to Vanescula on the bridge.
 * Talk to King Roald.
 * Quest complete!