The Lord of Vampyrium/Quick guide

Starting off

 * Talk to Vanescula Drakan at the docks, south-east of Burgh de Rott.

Gathering of the Myreque

 * Board the nearby boat to travel to the icyene graveyard and talk to Safalaan.
 * Solve the ring puzzle by rotating the rings until turn blue and their markings join together.
 * Inspect the statue of Queen Efaritay to receive Efaritay's pendant. Talk to Safalaan again.
 * Travel to the Myreque Hideout and enter the room in the centre of the hideout to play a cutscene.
 * Talk to Safalaan, who is located at the northern end of the hideout. Go through the dialogue.

Castle Drakan

 * Teleport to Darkmeyer and enter the Arboretum. Talk to Veliaf Hurtz.
 * Leave the Arboretum and go west to the city wall to find a group of vyrewatch. Talk to Overwatch Mornid.
 * Search the Vyrewatch crate in the large house south-east of the vyrewatch to obtain Vyrewatch uniforms. Return to Veliaf and talk to him, click yes to continue the quest.
 * Equip the House Drakan outfit and talk to Vanescula to enter Castle Drakan. No items other than the Darkmeyer outfit, House Drakan outfit, Drakan medallion, runes, Ivandis flail and blisterwood weapons and ammo can be taken to Castle Drakan.
 * Complete the following to gain status:
 * Talk to Lady Nadezhda Shadum - suggest that she humiliates the wolf (20 status).
 * Talk to Lord Alexei Jovkai - suggest that he tries the Defiant old man (20 status).
 * Talk to Lord Mischa Myrmel - suggest that she shows the blood tithe mercy (20 status).
 * Shoo all three bats (15 status each).
 * Talk to Vanescula again. Talk to Lord Drakan, choose any of the responses to Drakan's questions and finally choose to spring the trap or call the retreat. The player will be caught and put into a cell regardless of the choice made.

Escaping the cells

 * Leave the cell and open other cell doors to free the Myreque.
 * Go through the portcullis to the next chamber and solve the puzzle to free Vanescula and Mornid. This is similar to the earlier puzzle with the addition that rotating a ring causes the smaller, adjacent ring to rotate as well. Rotating the centre ring causes the outer ring to rotate.
 * Enter the next chamber and talk to Safalaan. Go up the stairs and leave the dungeon.
 * Enter the room on the eastern side of the corridor and take from the butchery table. Talk to Vanescula and Mornid in the room on the western side of the corridor,
 * Go to the room south of the corridor. Investigate each blood lock to assign a Myreque member to it. The correct matches are:
 * Ghrazi - Veliaf
 * Alzeph - Radigad
 * Pyrah - Kael
 * Myrmel - Mekritus
 * Vitur - Polmafi
 * Shadum - Vertida
 * Jovkai - Safalaan
 * Drakan - Ivan
 * Unlock the tithing door escape through the cellar exit. Enter the tunnel and Lord Drakan will appear.

Ascending the castle

 * Vandalise the Statue of Lord Drakan to obtain a statue spear and brace the entrance door.
 * A venator will break through a nearby window and attack the player. Defeat the venator and head upstairs.
 * Smash furniture to gain furniture debris and use this to barricade windows. If the status bar depletes with a window remaining uncovered then a venator will break through the window and the player will have to defeat it and finish barricading the windows before proceeding.
 * Use the blood lock to enter the next room. Obtain furniture debris and barricade the windows in the second room. Use the blood lock and enter the third room.
 * Click on the table to lift it.
 * Defeat the venator and click on the table again to finish lifting it into place. Use the third blood lock and enter the next room.
 * Barricade the windows. Solve the puzzle by making these moves:
 * Rotate ring A clockwise twice.
 * Rotate ring B clockwise once.
 * Rotate ring C clockwise three times.
 * Rotate ring D clockwise twice.
 * Rotate ring E clockwise once.
 * Rotate ring D clockwise once.
 * Rotate ring C anti-clockwise once.
 * Rotate ring B clockwise once.
 * Rotate ring A anti-clockwise once.
 * Climb the stairs.
 * Climb the stairs on the western and eastern sides of the chamber and open the blood valves in each room.
 * Enter the room north of the chamber and open a third blood valve.
 * Climb back down the stairs and solve the final puzzle by making these moves:
 * Turn ring A clockwise or anticlockwise four times.
 * Turn ring B anticlockwise twice.
 * Turn ring C anticlockwise twice.
 * Turn ring E anticlockwise three times.
 * Turn ring D anticlockwise three times.
 * Turn ring C clockwise three times.
 * Turn ring B anticlockwise three times.
 * Turn ring A clockwise three times.

Confronting Drakan

 * Climb the stairs surrounding the chamber and prepare to fight Lord Drakan.
 * Drakan will summon three venators. Kill them.
 * Now Drakan will fight the player. Run away from bombs which appear after Drakan saying "Ha ha ha!". When Drakan says things like "Still trying to run?" or "You think you can escape?" use Anticipation to avoid being stunned and dealt high damage.
 * Fight Drakan again. When Drakan says "Fear me!" and transforms into a cloud of dust, run away from the cloud. When says "Embrace darkness" stand next to Salafaan, within the sphere of lightening.
 * Jump into the portal, Drakan will appear again. Fight him - he will use the same attacks as in the previous fights.
 * Talk to Drakan and then fight him for the final time. Avoid bombs as before. Move away from Drakan when he is doing a special attack, performing rapid melee attacks, to avoid taking damage.

Finishing up

 * Use the "finish" option on Lord Drakan. Talk to Veliaf and go through the dialogue. Talk to Ivan and choose yes to continue the quest.
 * Go to Varrock Palace and talk to King Roald about Morytania.
 * Quest complete!