For the potion flask version, see Antipoison++ flask.
Antipoison++ detail

Antipoison++ are made by mixing clean irit and magic roots in a vial of coconut milk, requiring 79 Herblore and giving 177.5 Herblore experience.

Antipoison++ cures poison and provide the longest possible immunity to poison, which is 12 minutes. This makes them far more useful than other types of antipoison potions, eliminating the need to drink constantly.

If your antipoison is about to run out you'll get the message: "Your immunity to poison is about to expire."

Price per Dose

Item GE price Price per dose
Antipoison++ (1) Antipoison++ (1) 1,092 1,092
Antipoison++ (2) Antipoison++ (2) 2,276 1,138
Antipoison++ (3) Antipoison++ (3) 2,809 936
Antipoison++ (4) Antipoison++ (4) 3,266 817
Antipoison++ flask (6) Antipoison++ flask (6) 13,581 2,264


Antipoison++ (4) Antipoison++ (4)
Herblore-Make-X GE icon
177.5 XP-3,266
Herblore Herblore level79
P2P icon Members onlyYes
Antipoison++ (unf)Antipoison++ (unf)1N/A-
Magic rootsMagic roots13,5773,577


This potion can be made into an antipoison++ flask by using at least six doses of it with a potion flask. Players do not need a specific level to turn potions into flasks.

Production costs

Herb Secondary Vial Material cost Profit Profit/XP
Clean irit Clean irit Magic roots Magic roots Coconut milk Coconut milk 9,998 -7,189 -40.27
Grimy irit Grimy irit Magic roots Magic roots Coconut milk Coconut milk 9,770 -6,961 -37.16
N/A Magic roots Magic roots Irit potion (unf) Irit potion (unf) 7,437 -4,628 -26.07
Grimy iritClean irit + Coconut milk = Antipoison++ (unf)

Grimy irit is cleaned to become clean irit added to a vial of coconut milk to make antipoison++ (unf)

Antipoison++ (unf) + Magic roots = Antipoison++ (3)
Then add magic roots to make a 4-dose Antipoison++.

Antipoison protection comparison

  • Prices based on price for (3) dose potions. Expect some variation when buying potions decanted to other dose counts.
Antipoison Price/dose Seconds/dose Price/second
Antipoison (4) Antipoison 117.33 86 1.36
Super antipoison (4) Super antipoison 1,635.33 346 4.73
Antipoison+ (4) Antipoison+ 1,022.67 518 1.97
Antipoison++ (4) Antipoison++ 936.33 720 1.3
Sanfew serum (4) Sanfew serum 1,737 86 20.2

Drop sources

Antipoison++ potion (4)

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For an exhaustive list of all known sources for this item, see here.
Source Combat level Quantity Rarity
Corporeal Beast78540Uncommon


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