The Arboretum is the "vault" for the infamous Blisterwood tree, found in the upper tier of Darkmeyer. Lord Drakan had spent centuries attempting to destroy the tree, but failed. He simply locked it up in the building. It is meant to keep the Blisterwood tree, an extremely dangerous wood to vampyres, out of accessible hands.

During The Branches of Darkmeyer, the Arboretum is guarded by Lord Drakan's brother, Ranis Drakan, who eventually discovers the player's identity and traps them inside this building.

The building is free from vampyres and can only be entered with sufficient ranking in Darkmeyer.

The fastest way to travel here after completing The Branches of Darkmeyer quest is to use Drakan's medallion.

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