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Reasoning:

Grimy herbs: Grimy herbs are frequently cheaper than their clean alternatives and the experience from cleaning them is not negligible, as opposed to making unfinished potions. If profit/expenditure is your main concern, cleaning your own herbs and making your own unfinished potions is worth the time.

Portable well: The portable well boosts Herblore experience by 10% and give a 5% chance of making an extra potion. This 5% is applied when making unfinished potions and again when finishing potions with secondary ingredients. Portable wells are frequently hosted at the Combat academy, which you can use at no cost to you, though it is nice to help out the community by deploying some portable wells that you have purchased.

Scroll of cleansing: The scroll of cleansing can be purchased from Marmaros Thokson in Daemonheim for 20,000 Dungeoneering tokens. The scroll gives a 12.5% chance that a potion will be created twice as fast as usual. The scroll also gives a 10% chance of salvaging an herb added to a vial of water and salvaging a secondary ingredient when added to an unfinished potion.

Decanting to flasks: Decanting to flasks does not always increase profit. To see if decanting is profitable, check the Calculator:Herblore/Flask decanting page. However, decanting to flasks can be done for free, in bulk (noted items), and almost instantly with the help of Teplin Macagan after completion of As a First Resort. Because this can be done so quickly, can be immensely profitable, and if profit is your motive, I highly suggest only making potions which are profitable to decant.


Process:

The following is the process to replicate (as close as possible) the optimal calculations shown in the below table. Buying 1,000 herbs was used as a way to calculate more accurate averages for the sake of representation. With smaller sample sizes, results will vary more widely, but over time will average out to the calculations shown in the below table.

1. Buy 1,000 grimy variants of the herb for your selected potion. Herbs can be slower to purchase at GE market prices, but the more profitable potions can still turn a significant profit even while buying herbs at higher than market price.

2. Clean your grimy herbs. This is done fastest by setting a Bank preset for quick withdrawing.

3. Find a world where a Portable well is being hosted. This information can be found by searching for 'portable locations' in the Runescape forums.

4. Add your herbs to vials of water using the portable well. By adding 1,000 herbs to vials of water, you will yield (on average) 1050 unfinished potions due to the effect of the portable well. Due to the effect of the scroll of cleansing, you will have saved (on average) 100 herbs. By adding those 100 herbs to vials of water, you will yield (on average) 105 unfinished potions and saved (on average) 10 herbs. By adding those 10 herbs to vials of water, you will yield (on average) 10 unfinished potions and saved (on average) 1 herb. This herb (on average) will make 1 unfinished potion and will not be saved. This process will yield in total, and of course on average, 1,166 unfinished potions and use 1,111 vials of water.

5. Due to the 10% chance to save secondary ingredients, your 1,166 unfinished potions will require (on average) 1,060 secondary ingredients. (1,060 * 1.1 = 1,166) Buy a little more than this amount (to avoid having to go back to the Grand exchange) and add them to your unfinished potions at the portable well. The 5% chance to make an extra potion will be applied again over this process at the portable well. This will yield (on average) 1,224 finished 3-dose potions.

6. Buy 612 Potion flasks at the Grand exchange. Bring your noted potion flasks and noted 3-dose potions to Teplin Macagan and have him decant your potions into your flasks. Sell these flasks at the grand exchange. It may take some ime for your flasks to sell at market prices, but again the more profitable potions may still turn a significant profit even selling at a little lower than market price.

Potion Level
Req.
XP Cost of 1K Grimy Herbs
& 1111 Vials
Cost of 1060
Secondary Ingredients
Cost of 612
Potion Flasks
Total Cost Price of 612
Full Flasks
Profit/Loss
Per Potion


Attack potion (3) Attack potion 1 25 815,656 10,600 4,014,720 4,840,976 4,052,664 -644.05
Ranging potion (3) Ranging potion 3 30 815,656 636,000 4,014,720 5,466,376 7,389,900 1,571.51
Magic potion (3) Magic potion 5 35 211,656 1,064,240 4,014,720 5,290,616 6,991,488 1,389.6
Strength potion (3) Strength potion 7 4 211,656 5,501,400 4,014,720 9,727,776 4,884,372 -3,957.03
Defence potion (3) Defence potion 9 45 2,413,656 960,360 4,014,720 7,388,736 6,446,196 -770.05
Antipoison (3) Antipoison 13 50 2,413,656 1,780,800 4,014,720 8,209,176 5,570,424 -2,155.84
Guthix rest (3) Guthix rest 18 59.5 847,656 2,445,420 4,014,720 7,307,796 13,438,296 5,008.58
Restore potion (3) Restore potion 22 62.5 847,656 1,489,300 4,014,720 6,351,676 4,573,476 -1,452.78
Energy potion (3) Energy potion 26 67.5 847,656 519,400 4,014,720 5,381,776 5,492,088 90.12
Agility potion (3) Agility potion 34 80 11,356,656 630,700 4,014,720 16,002,076 6,179,976 -8,024.59
Combat potion (3) Combat potion 36 84 847,656 3,074,000 4,014,720 7,936,376 6,679,980 -1,026.47
Prayer potion (3) Payer potion 38 87.5 1,966,656 142,040 4,014,720 6,123,416 6,843,384 588.21
Summoning potion (3) Summoning potion 40 92 16,681,656 7,476,180 4,014,720 28,172,556 26,918,208 -1,024.79
Divination potion (3) Divination potion 43 97.5 16,681,656 5,927,520 4,014,720 26,623,896 2,965,140 -19,329.05
Super attack (3) Super attack 45 100 5,114,656 10,600 4,014,720 9,139,976 9,283,428 117.2
Super antipoison (3) Super antipoison 48 106.3 5,114,656 1,780,800 4,014,720 10,910,176 13,720,428 2,295.96
Fishing potion (3) Fishing potion 50 112.5 1,149,656 142,040 4,014,720 5,306,416 4,328,064 -799.31
Super energy (3) Super energy 52 117.5 1,149,656 3,638,980 4,014,720 8,803,356 7,983,540 -669.78
Hunter potion (3) Hunter potion 53 120 1,149,656 13,227,740 4,014,720 18,392,116 26,488,584 6,614.76
Runecrafting potion (3) Runecrafting potion 54 122.5 2,807,656 129,320 4,014,720 6,951,696 2,069,172 -3,988.99
Super strength (3) Super strength 55 125 11,888,656 5,501,400 4,014,720 21,404,776 20,283,516 -916.06
Fletching potion (3) Fletching potion 58 132 2,807,656 699,600 4,014,720 7,521,976 4,138,956 -2,763.91
Weapon poison (3) Weapon poison 60 137.5 11,888,656 662,500 4,014,720 16,565,876 3,652,416 -10,550.21
Super restore (3) Super restore 63 142.5 1,895,656 1,489,300 4,014,720 7,399,676 7,101,648 -243.49
Super defence (3) Super defence 66 150 4,428,656 4,260,140 4,014,720 12,703,516 12,528,864 -142.69
Antipoison+ (3) Antipoison+ 68 155 11,356,656 1,061,060 4,014,720 16,432,436 15,683,112 -612.19
Antifire (3) Antifire 69 157.5 7,657,656 662,500 4,014,720 12,334,876 12,980,520 527.49
Super ranging potion (3) Super ranging potion 72 162.5 8,582,656 16,324,000 4,014,720 28,921,376 28,319,076 -492.08
Super magic potion (3) Super magic potion 76 172.5 7,657,656 5,563,940 4,014,720 17,236,316 15,701,472 -1,253.96
Invention potion (3) Invention potion 77 175 1,895,656 58,300 4,014,720 5,968,676 2,790,720 -2,596.37
Zamorak brew (3) Zamorak brew 78 175 5,495,656 917,960 4,014,720 10,428,336 5,683,644 -3,876.38
Antipoison++ (3) Antipoison++ 79 177.5 5,114,656 4,242,120 4,014,720 13,371,496 11,164,716 -1,802.92
Saradomin brew (3) Saradomin brew 81 180 11,356,656 7,242,980 4,014,720 22,614,356 23,435,316 670.72
Aggression potion (3) Aggression potion 82 185 16,689,656 58,816,220 4,014,720 79,520,596 82,541,052 2,467.69
Prayer renewal (3) Prayer renewal 94 190 6,966,656 5,345,580 4,014,720 16,326,956 11,044,152 -4,316.02
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