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This article is about the type of rune. For the minigame rune, see catalytic rune.

Catalytic runes are all the runes that are not elemental runes. They include Mind runes, Body runes, Chaos runes, Death runes, Cosmic runes, Law runes, Nature runes, Blood runes, Astral runes, and Soul runes. All of these can be crafted using the Runecrafting skill. However, the only non-elemental runes free players can craft are mind runes and body runes. Body, Mind, Chaos, and Death runes can be bought at the two Magic stores (in Varrock and Port Sarim) in free-to-play worlds.

Non-elemental runes are also sometimes called base runes, or catalytic runes (before the Fist of Guthix minigame). There are special runes called catalytic runes used in the Fist of Guthix minigame. Each rune can act as either one Mind rune, Body rune, Chaos rune, Death rune, Cosmic rune, Law rune, or Nature rune. At the beginning of the game each player receives 300 catalytic runes.

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