Essence may refer to:
- Rune essence
- Rune Essence mine, where the raw and uncharged runes can be mined
- Rune essence, which can be crafted into lower level runes; has no requirements to mine this resource
- Pure essence, which can be crafted into any rune; requires level 30 mining and membership to mine this resource
- Rune essence (Runespan), used in the Runespan
- Floating essence, the easiest source of this essence
- Essence creature, also found in RuneSpan
- Unstable essence, stackable essence bought with Runespan points.
- Rune essence (Dungeoneering), used in Daemonheim
- Rune essence (Rune Mechanics), used in Rune Mechanics
- Rune Essence, the music track
- The Heart
- Discontinued
- Rose essence truffle, a discontinued Squeal of Fortune item
- Essence of wisdom, a discontinued Treasure Hunter item
- Runic Essence Wings
- Other
- Carwen Essencebinder, Runecrafting skill tutor
- Carwen Essencebinder Magical Runes Shop, her rune shop
- Essence impling
- Essence shipment scroll, special move of the abyssal titan familiar
- Magic essence potion
- Ghostly essence, a drop from ghosts
- Ruined essence, part of the Mod Deg trading sequence
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