Frank may refer to:
- Frank Sinclair, one of the suspects in the Murder Mystery quest
- Frank's mark, an item used in the Rocking Out quest
- Frank (Poison Arrow), a man in the Poison Arrow pub
- Frank (The Horsemen), the starting NPC of the 2011 Hallowe'en event and temporary replacement of Death for Soul Reaper
- Redbeard Frank, a pirate in Port Sarim
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