|425,300 per hour|
4,440 Death runes (528,360)
At average speed, one can do about 60 trips to the death altar via the Abyss per hour, using the amulet of glory to teleport back to Edgeville, and using the tool belt items to mine through the rocks in the abyss. You need to recharge your pouches every 7 to 9 trips, to prevent the giant pouch from degrading.
The Mage of Zamorak is located low-level wilderness, near the source of the River Lum. This is a fairly safe area, but there might be player killers so it is advised not to take expensive items on the trips to the abyss. It is also a good idea to use a less-populated world. The best setup would be cheap but protective gear. Inside the abyss, the creatures there will be aggressive and might do fair amounts of damage. See Abyss#Strategy for more information on how to navigate the abyss. Once inside, enter the death rift and craft the essence in your inventory and your pouches. Teleport back to Edgeville with an amulet of glory and repeat.
The amount of death runes crafted increases at higher levels, up to about 30% at 99, due to the greater likelihood of crafting two runes per essence. This results in a increase of up to 1,332 Death runes created per hour, equivalent to an extra 158,508 in profit.
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