The Nihil damage enhancer is a possible item received from the Motherlode Maw's daily random reward if you have at least level 95 in all skills. You also have a chance of getting it by trading Wythien ten crystal motherlode shards, or you can talk to Wythien to convert an unfocused damage enhancer to a Nihil damage enhancer, but it will only have 75 charges instead of 150.

When the enhancer is in your inventory, you will do 10% more damage against nihil. This lasts for 150 successful hits, after which the enhancer will disappear.

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