Protect from Summoning is a prayer accessible at level 35 Prayer, which is the lowest requirement of any of the "Protect from" prayers. When used, the player receives protection against NPC's summoned by other NPC's and enemy familiars.
Players using this prayer will have a wolf icon above their character. They can also use any of the other protection prayers simultaneously with the Protect from Summoning prayer. The image of the Protect from Summoning and the other protection prayer will both be displayed, and both prayers' protection capabilities will be in effect at the same time.
Protect from Summoning will grant you 50% damage reduction against most attacks and special attacks from familiars. Also, the player will be immune to any of the familiars' right-click abilities. Note that certain familiars, including the Steel Titan, ignore Protect from Summoning, and will still hit as high and accurately as if it was not on.