The Refined Anima Core helm of Seren is part of the Anima Core of Seren set. It can be made at level 80 Crafting by combining an Anima Core helm of Seren with 1 of each of the essences - Serenic, Sliskean, Zamorakian, and Zarosian - after the ability to craft Refined Anima Core of Seren armour has been unlocked by earning 2,000 Serenist reputation. Crafting it grants 500 Crafting experience.
The helm degrades back to an unrefined helm after 100,000 charges of combat, where it can be crafted again using more essences. It can also be restored to 100% charge at any time using 1 of each essence (essentially re-creating it).