Snake may refer to:
- Big Snake, found in a cave on Crash Island
- Bush snake, poisonous snakes around Tai Bwo Wannai
- Desert snake, found in the Kharidian Desert
- Juna, a Guardian of Guthix protecting the Tears of Guthix
- Jungle snake, found on Ape Atoll
- Sea snakes found in the Miscellania and Etceteria Dungeon:
- Snake, non-poisonous snakes on Karamja
- Snake (poisonous), found on Mos Le'Harmless
- Swamp snake, encountered during Temple Trekking and Burgh De Rott Ramble
- Tinsel Snake, animated Christmas decorations, including Sparkles
- Spirit cobra, a Summoning familiar
- Icxan, a wounded snake to be healed during the Zodiac Training event
- Snakeskin, a crafting material used to make Snakeskin armour (requires level 30 Ranged and Defence)