For the standard variant, see Soul rune.
Soul runes in Dungeoneering are used to cast various Magic spells. They can be obtained as a drop from various monsters. 1 type of rune or arrow can be bound to the ammo slot, holding up to 125 (or 225 after completing Salt in the Wound) runes. Soul runes are not a recommended bind as non-damaging spells have little use inside dungeons.