The supreme defence potion is a six-dose combination potion that can be made at level 93 Herblore after buying the recipe for 500,000 coins from Lady Meilyr (you do not need to find this recipe in Daemonheim). It is made by combining a super defence (4) and an extreme defence (4) in a crystal flask, giving 292.5 experience.
A dose of supreme defence boosts Defence by 16% of your Defence level, plus 4, rounded down; this provides an additional 2 levels over extreme defence at level 99 for a final level of 118.
Supreme defence potion (6)
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