The tireless blood essence is one of the blood essences players can craft after the quest River of Blood. Using Haemalchemy, players can combine 100 congealed blood with a 4-dose super restore potion; doing so requires at least 500 vyre corpses to be cremated in the Columbarium. If chosen as the one-time gift from Vanescula Drakan after the quest or created manually, it will have 1,000 charges. Additional charges can be added by using more congealed blood on the essence, giving 10 charges each, to a maximum of 5,000 charges. If charges are completely exhausted, the essence's effects no longer function, but it can still be worn.
When worn, it has a passive effect that has a chance of restoring adrenaline upon killing an NPC. The amount restored is based on the NPC's maximum life points, to a maximum of 2%. When activated, it restores 15% adrenaline.
The active effect can be used once per two minutes. This cooldown is shared with potions that restore adrenaline, but it is not shared with other blood essences. Each passive effect consumes 1 charge and each active effect consumes 50 charges.
Having a blood essence equipped and attempting to enter the Mausoleum notifies the player "You have a blood essence equipped which makes the ravenous ghouls aggressive. Are you sure you wish to proceed?"
According to the book Haemalchemy (Vol. 2), this blood essence is described as:
Duplicates any epinephrine molecules in your blood plasma to grant a sudden energy boost. Do not activate this blood essence often in short timeframes.
| Requirements | Tier | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| None | None | ||||||||||
| Class | Slot | Attributes | |||||||||
| None |  |  Armour | 0 | ||||||||
 Life points | 0 | ||||||||||
| Weapons | Main | Off |  Prayer | 0 | |||||||
| Damage | - | - | Damage reduction | ||||||||
| Accuracy | - | - | PvM: 0% | PvP: 0% | |||||||
| Style | - | Style bonuses | |||||||||
| Range | - |  0 |  0 |  0 | |||||||
| [FAQ] • [doc] | |||||||||||
| Cost of charges | ||
|---|---|---|
| Blood essence | Price per 1 passive effect | Price per activate |
| Tireless | 6.9 | 345 |
| Cost of producing | ||
| Super restore (4) | Congealed blood x100 | Total price |
| 2,798 | 6,900 | 9,698 |
| Blood essences |
 Vampyric Penance Aegis Reflecting Berserk Tireless |
