Wyrm may refer to:
- Wyrms, the ancient ancestors of dragons
- Desert wyrm, the Summoning familiar
- Strykewyrm, a race of wyrms
- Desert strykewyrm, a monster requiring 77 Slayer to kill
- Ice strykewyrm, a monster requiring 93 Slayer to kill
- Jungle strykewyrm, a monster requiring 73 Slayer to kill
- Lava strykewyrm, a monster requiring 94 Slayer to kill
- WildyWyrms, a monster related to strykewyrms
- Wyrm scalp, an item used to create the strykebow
- Wyrm spike, an item used to create the lava whip
- Wyrm heart, an item used to create the staff of darkness