多重戰鬥區域(multicombat area),也稱作Multiway Combat area,在區域內玩家或怪物可以攻擊多個目標。
當玩家進入多重戰鬥區域,畫面上會多一個交叉的劍的圖案(), 只有在此區域可以攻擊多個目標,其他地方只能進行1對1的戰鬥。
在蠻荒之地,多重戰鬥區域是很危險的,玩家可能一次受到多個玩家或怪物的攻擊,但同時也很有用,玩家可以和朋友一起擊敗怪物或玩家,單獨前往可能很容易就被擊敗。

運用障礙物,即使不在多重戰鬥區域也能夠攻擊多個目標
注意,當你使用魔法/弓箭攻擊怪物,同時有障礙物阻擋在中間,怪物無法攻擊時,玩家便可以一次攻擊多個目標,即使不是在多重戰鬥區域也能使用。
下面列出各個多重戰鬥區域的所在位置:
- The Abyss
- Al Kharid palace in Al Kharid
- Ape Atoll
- Bandit Camp in the Kharidian Desert.
- Barbarian Assault
- Barbarian Village
- Battlefield south of West Ardougne
- South of Burthorpe Games
- Chaos Tunnels
- The clay mine northeast of Draynor Village (which is weird because there aren't any monsters in that area)
- The Corporeal Beast lair
- Castle Wars
- The entirety of the dungeons of Daemonheim
- Jail area in Draynor Village
- Duel Arena
- Most sections of Falador, including the White Knight's Castle
- Falador Mole Lair
- Fight Pits in TzHaar City
- God Wars Dungeon
- Jatizso Ice troll area
- Kalphite Lair
- Lighthouse Dungeon
- Neitiznot ice troll area
- West of Oo'glog
- Ork's Rift
- Ourania Cave
- Pest Control
- Phoenix Lair
- Player-owned house dungeons and fight arenas
- Pollnivneach Slayer Dungeon
- Ranging Guild
- The northern coast of the Fremennik Province
- Soul Wars
- Stealing Creation
- The Stronghold of Player Safety
- The first level of the Stronghold of Security
- The Tormented Wraith room in the spirit realm
- TzHaar City
- Varrock Sewers
- Waterbirth Island Dungeon
- White Wolf Mountain
- Several places in the Wilderness including the areas at or around:
- The Abandoned Farm
- The Wilderness Bandit Camp
- The Chaos Temple hut in the western Wilderness (not the Chaos Temple in the eastern Wilderness)
- The Dark Warriors' Fortress
- The Deadly red spiders
- The Deep Wilderness Castle Ruins
- The Demonic Ruins
- The Graveyard of Shadows
- The Lava Maze
- Red Dragon Isle
- Rogues' Castle
- The Scorpion Pit
- The southern part of the Wilderness Agility Course
- Wilderness North Volcano
- Wizards' Tower